Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MMP2 | P08253 | 3/20 | 0.61 |
| ▸ | MMP7 | P09237 | 2/20 | 0.61 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
| ▸ | MMP3 | P08254 | 1/20 | 0.61 |
| ▸ | MMP9 | P14780 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | GRN | P28799 | 1/20 | 0.56 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | SUMO3 | P55854 | 1/20 | 0.47 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.47 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062306 | 0.85 | MMP2 (0.69) | KDM4EMMP2MMP7MMP1MMP3 | |
| SCHEMBL8840147 | 0.85 | MMP2 (0.69) | KDM4EMMP2MMP7MMP1MMP3 | |
| SCHEMBL29362524 | 0.82 | KDM4E (0.64) | RAB9AKDM4EMMP2MMP7MMP1 | |
| SCHEMBL7066879 | 0.82 | MMP2 (0.69) | KDM4EMMP2MMP7MMP1MMP3 | |
| SCHEMBL7066619 | 0.80 | MMP9 (0.71) | KDM4EMMP2MMP7MMP1MMP3 | |
| SCHEMBL3969625 | 0.80 | MMP9 (0.71) | KDM4EMMP2MMP7MMP1MMP3 | |
| SCHEMBL11351046 | 0.80 | MMP9 (0.71) | KDM4EMMP2MMP7MMP1MMP3 | |
| SCHEMBL4342387 | 0.80 | RAB9A (0.62) | RAB9AMMP2MMP7MMP1MMP3 | |
| SCHEMBL4342394 | 0.80 | RAB9A (0.62) | RAB9AMMP2MMP7MMP1MMP3 | |
| SCHEMBL5138984 | 0.80 | KDM4E (0.61) | KDM4EMMP2MMP7MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030130251-A1 | Amino lactam sulfonamides as inhibitors of A-beta protein production | THOMPSON LORIN A (US) | 2003-07-10 | — | — | US | claimed |
| US-6503901-B1 | Alzheimer*s disease and Down*s syndrome treatment | BRISTOL MYERS SQUIBB PHARMA COMPANY | 2003-01-07 | — | — | US | claimed |
| US-20030130251-A1 | Amino lactam sulfonamides as inhibitors of A-beta protein production | THOMPSON LORIN A (US) | 2003-07-10 | — | — | US | disclosed |
| US-6503901-B1 | Alzheimer*s disease and Down*s syndrome treatment | BRISTOL MYERS SQUIBB PHARMA COMPANY | 2003-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130251-A1 | Amino lactam sulfonamides as inhibitors of A-beta protein production | APP, APH1A, BACE1 | RAB9A 1258/4885KDM4E 3988/4885MMP2 1807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.