Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | CCR8 | P51685 | 5/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CCR3 | P51677 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067554 | 0.89 | CCR8 (0.58) | SIGMAR1CCR8MCHR1CCR5KCNH2 | |
| SCHEMBL7066532 | 0.84 | RAB9A (0.52) | SIGMAR1MCHR1CCR5LTA4HHTR2A | |
| SCHEMBL7155259 | 0.79 | CCR8 (0.68) | SIGMAR1CCR8KCNH2DRD4 | |
| SCHEMBL6504896 | 0.77 | CCR8 (0.88) | SIGMAR1CCR8 | |
| SCHEMBL3164487 | 0.77 | SIGMAR1 (0.74) | SIGMAR1MCHR1MAPK1DRD4 | |
| SCHEMBL12511819 | 0.74 | SIGMAR1 (0.70) | SIGMAR1MCHR1MAPTMAPK1CCR5 | |
| SCHEMBL9727102 | 0.73 | SIGMAR1 (0.72) | SIGMAR1MCHR1LTA4HKCNH2CCR3 | |
| SCHEMBL1367578 | 0.73 | CCR8 (0.56) | SIGMAR1CCR8MCHR1MAPTMAPK1 | |
| SCHEMBL3590338 | 0.72 | SIGMAR1 (0.73) | SIGMAR1MCHR1MAPTDRD4 | |
| SCHEMBL5175893 | 0.72 | MCHR1 (0.72) | SIGMAR1MCHR1LTA4HKCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003037271-A2 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS,INC. (US) | 2003-05-08 | — | — | WO | disclosed |