Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.35 |
| ▸ | F11 | P03951 | 3/20 | 0.35 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29652456 | 0.76 | MAPT (0.51) | MAPK14LCKLTB4RTP53MAPT | |
| SCHEMBL6089216 | 0.76 | MAPT (0.51) | MAPK14LCKLTB4RTP53MAPT | |
| Hydrochloric Acid SCHEMBL6089209 | 0.75 | MAPT (0.50) | MAPK14LCKLTB4RTP53MAPT | |
| SCHEMBL5057415 | 0.70 | ALDH1A1 (0.46) | MAPT | |
| SCHEMBL16149782 | 0.69 | HDAC4 (0.56) | MAPK14ABL1BCRJAK2 | |
| SCHEMBL27483625 | 0.69 | CA12 (0.52) | ABL1BCRMAPTRAB9A | |
| SCHEMBL8894615 | 0.69 | SMN1; SMN2 (0.52) | MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8003997 | 0.69 | MAPK14 (0.40) | MAPK14F9F11MAPTRAB9A | |
| SCHEMBL20013249 | 0.69 | LMNA (0.44) | TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9212282 | 0.69 | F9 (0.45) | MAPK14LCKCSF1RF9KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135023-A4 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | LILLY CO ELI (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1135023-A1 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | ELI LILLY AND COMPANY (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000027199-A1 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | ELI LILLY AND COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000027627-A1 | ARYLOXIME LINKERS IN THE SOLID-PHASE SYNTHESIS OF 3-AMINOBENZISOXAZOLES | ELI LILLY AND COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |