SCHEMBL6089216

SCHEMBL6089216

COC(=O)c1ccc2c(N)noc2c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.51
KDM4E B2RXH2 3/20 0.51
HSD17B10 Q99714 3/20 0.51
ALDH1A1 P00352 2/20 0.51
HPGD P15428 2/20 0.51
GLA P06280 1/20 0.51
GAA P10253 1/20 0.51
CASP1 P29466 1/20 0.51
CASP7 P55210 1/20 0.51
ATM Q13315 1/20 0.51
MAPK14 Q16539 1/20 0.47
CREBBP Q92793 1/20 0.44
LTB4R Q15722 1/20 0.44
HIF1A Q16665 1/20 0.44
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
CA2 P00918 2/20 0.44
CA7 P43166 2/20 0.44
CA9 Q16790 2/20 0.44
CA14 Q9ULX7 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29652456 1.00 MAPT (0.51) MAPTKDM4EHSD17B10ALDH1A1HPGD
Hydrochloric Acid SCHEMBL6089209 0.98 MAPT (0.50) MAPTKDM4EHSD17B10ALDH1A1HPGD
SCHEMBL6089113 0.88 MAPT (0.47) MAPTKDM4EHSD17B10ALDH1A1HPGD
SCHEMBL5917980 0.83 BRD4 (0.46) MAPTKDM4EHSD17B10ALDH1A1HPGD
SCHEMBL21596905 0.81 MAPK14 (0.44) MAPTKDM4EHSD17B10ALDH1A1HPGD
SCHEMBL15659098 0.79 HIF1A (0.43) MAPTKDM4EHSD17B10ALDH1A1HPGD
SCHEMBL21596890 0.78 ALDH1A1 (0.47) MAPTKDM4EALDH1A1HPGDGLA
SCHEMBL9212282 0.77 F9 (0.45) KDM4EHSD17B10ALDH1A1HPGDMAPK14
SCHEMBL30204320 0.76 CSNK2A2 (0.46) MAPK14CREBBPHIF1APARP1NPC1
SCHEMBL7067692 0.76 MAPK14 (0.48) MAPTMAPK14LTB4RLCKSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 US disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed
US-20060235222-A1 Indole-derivative modulators of steroid hormone nuclear receptors ELI LILLY AND COMPANY (US) 2006-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 MAPT 1135/4885KDM4E 4009/4885HSD17B10 298/4885
US-20200039945-A1 Compounds SLC10A1, ABCB11, PCSK9 MAPT 1136/4885KDM4E 4009/4885HSD17B10 299/4885
US-20060235222-A1 Indole-derivative modulators of steroid hormone nuclear receptors NR3C2, NR5A1, MC2R MAPT 4025/4885KDM4E 3154/4885HSD17B10 229/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.