Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Tetrabuthylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CHRNA10 | Q9GZZ6 | 3/20 | 0.39 |
| ▸ | CHRNA9 | Q9UGM1 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrabuthylammonium SCHEMBL7069227 | 0.96 | ALDH1A1 (0.52) | ALDH1A1TSHRSLC22A1CHRNA7LMNA | |
| Tetrabuthylammonium SCHEMBL28735164 | 0.88 | SLC22A1 (0.52) | ALDH1A1TSHRSLC22A1CHRNA7CHRNB2 | |
| Styrene SCHEMBL11801013 | 0.88 | ALDH1A1 (0.67) | ALDH1A1TSHRLMNADNM1TDP1 | |
| Styrene SCHEMBL1194200 | 0.88 | ALDH1A1 (0.67) | ALDH1A1TSHRLMNADNM1TDP1 | |
| Styrene SCHEMBL10418619 | 0.88 | ALDH1A1 (0.47) | ALDH1A1TSHRSLC22A1CHRNA7LMNA | |
| Dodecane SCHEMBL27503014 | 0.86 | ALDH1A1 (0.64) | ALDH1A1TSHRLMNADNM1TDP1 | |
| Styrene SCHEMBL1074288 | 0.86 | ALDH1A1 (0.64) | ALDH1A1TSHRLMNADNM1TDP1 | |
| Hexadecane SCHEMBL27958494 | 0.86 | ALDH1A1 (0.64) | ALDH1A1TSHRLMNADNM1TDP1 | |
| Styrene SCHEMBL10418638 | 0.85 | ALDH1A1 (0.44) | ALDH1A1TSHRSLC22A1CHRNA7DNM1 | |
| Styrene SCHEMBL10417913 | 0.85 | ALDH1A1 (0.44) | ALDH1A1TSHRSLC22A1CHRNA7DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514637-B2 | Alkaline cell with cathode surface protector | THE GILLETTE COMPANY | 2003-02-04 | — | — | US | disclosed |
| WO-2000059052-A9 | ALKALINE CELL SEPARATOR | GILLETTE CO (US) | 2002-06-20 | — | — | WO | disclosed |
| US-20010028976-A1 | Alkaline cell with improved separator | DURACELL U.S. OPERATIONS, INC. | 2001-10-11 | — | — | US | disclosed |
| WO-2000059052-A2 | ALKALINE CELL SEPARATOR | THE GILLETTE COMPANY (US) | 2000-10-05 | — | — | WO | disclosed |