Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 11/20 | 0.53 |
| ▸ | THRB | P10828 | 11/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7073270 | 0.89 | RORC (0.52) | THRATHRBFFAR1 | |
| SCHEMBL4561125 | 0.79 | THRA (0.74) | THRATHRB | |
| SCHEMBL5381968 | 0.78 | XIAP (0.48) | THRATHRBFFAR1 | |
| SCHEMBL7069931 | 0.77 | THRA (0.53) | THRATHRB | |
| SCHEMBL8631679 | 0.77 | THRB (0.51) | THRATHRB | |
| SCHEMBL7643749 | 0.75 | THRB (0.58) | THRATHRB | |
| SCHEMBL7069850 | 0.75 | THRA (0.73) | THRATHRB | |
| SCHEMBL5388465 | 0.75 | THRA (0.57) | THRATHRBFFAR1 | |
| SCHEMBL8059520 | 0.74 | THRB (0.49) | THRATHRB | |
| SCHEMBL5387101 | 0.74 | THRA (0.52) | THRATHRBFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000008-B1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KAROBIO AB (SE) | 2003-06-25 | — | — | EP | claimed |
| US-6465687-B1 | SUBSTITUTED 4-HYDROXY-3-ALKYL- OR CYCLOALKYL-PHENOXYBENZENE COMPOUNDS SUCH AS 3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYLPHENOXY)BENZOIC ACID, EXPRESSION INHIBITION OF A T3 REGULATED GENE | KARO BIO AB (SE) | 2002-10-15 | — | — | US | claimed |
| EP-1000008-B1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KAROBIO AB (SE) | 2003-06-25 | — | — | EP | disclosed |
| US-6465687-B1 | SUBSTITUTED 4-HYDROXY-3-ALKYL- OR CYCLOALKYL-PHENOXYBENZENE COMPOUNDS SUCH AS 3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYLPHENOXY)BENZOIC ACID, EXPRESSION INHIBITION OF A T3 REGULATED GENE | KARO BIO AB (SE) | 2002-10-15 | — | — | US | disclosed |
| EP-1000008-A1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KARO BIO AB (SE) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999000353-A1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KARO BIO AB (SE) | 1999-01-07 | — | — | WO | disclosed |