SCHEMBL8059520

SCHEMBL8059520

CC(C)c1cc(Oc2ccc3cc2-3)ccc1O.O=C(O)C(Cl)CCl

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 11/20 0.49
THRA P10827 10/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dichloroacetic Acid SCHEMBL4351126 0.90 THRB (0.51) THRBTHRA
SCHEMBL8057619 0.89 RORC (0.46) THRBTHRA
SCHEMBL8047080 0.87 THRB (0.50) THRBTHRA
Dibromoacetic Acid SCHEMBL8059529 0.85 THRB (0.51) THRBTHRA
SCHEMBL8064350 0.84 THRB (0.47) THRBTHRA
SCHEMBL8058793 0.80 THRA (0.43) THRBTHRA
SCHEMBL8057622 0.78 THRB (0.42) THRBTHRA
SCHEMBL7193319 0.75 THRB (0.47) THRBTHRA
SCHEMBL7069860 0.74 THRA (0.53) THRBTHRA
Dibromoacetic Acid SCHEMBL8047059 0.73 THRB (0.46) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1000008-A1 NOVEL THYROID RECEPTOR LIGANDS AND METHOD KARO BIO AB (SE) 2000-05-17 EP claimed
WO-1999000353-A1 NOVEL THYROID RECEPTOR LIGANDS AND METHOD KARO BIO AB (SE) 1999-01-07 WO claimed
EP-1000008-A1 NOVEL THYROID RECEPTOR LIGANDS AND METHOD KARO BIO AB (SE) 2000-05-17 EP disclosed
WO-1999000353-A1 NOVEL THYROID RECEPTOR LIGANDS AND METHOD KARO BIO AB (SE) 1999-01-07 WO disclosed