Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653912 | 0.84 | HDAC4 (0.74) | GPR119HDAC4MEN1KMT2AJAK2 | |
| SCHEMBL4422414 | 0.84 | GPR119 (0.67) | GPR119MAPTHDAC4MEN1KMT2A | |
| SCHEMBL7074329 | 0.81 | MAPT (0.59) | MAPTMEN1KMT2ALMNAHPGD | |
| SCHEMBL7129860 | 0.81 | GPR119 (0.61) | GPR119MAPTHDAC4KMT2AJAK2 | |
| SCHEMBL7071589 | 0.79 | GPR119 (0.59) | GPR119MAPTHDAC4JAK2JAK1 | |
| SCHEMBL7648133 | 0.79 | MAPT (0.59) | MAPTLMNAHPGDHTTPOLB | |
| SCHEMBL19970869 | 0.79 | MAPT (0.69) | GPR119MAPTMEN1KMT2ALMNA | |
| SCHEMBL7653492 | 0.78 | CNR1 (0.61) | MAPTHDAC4NAMPT | |
| SCHEMBL7649408 | 0.78 | DGAT1 (0.58) | MAPTHDAC4LMNADGAT1POLB | |
| SCHEMBL7254923 | 0.78 | GPR119 (0.57) | GPR119HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |