Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | GPR4 | P46093 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7129860 | 0.85 | GPR119 (0.61) | GPR119HDAC4LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7653912 | 0.83 | HDAC4 (0.74) | GPR119HDAC4JAK2JAK1 | |
| SCHEMBL4422414 | 0.82 | GPR119 (0.67) | GPR119HDAC4LMNAMAPTNPC1 | |
| SCHEMBL7071693 | 0.82 | LMNA (0.55) | HDAC4GPR4LMNAHPGDMAPT | |
| SCHEMBL7070014 | 0.79 | GPR119 (0.61) | GPR119HDAC4LMNAHPGDMAPT | |
| SCHEMBL7649098 | 0.79 | GPR119 (0.54) | GPR119HDAC4LMNAMAPTNPC1 | |
| SCHEMBL1448104 | 0.78 | GPR119 (0.66) | GPR119HDAC4 | |
| SCHEMBL7254923 | 0.78 | GPR119 (0.57) | GPR119HDAC4 | |
| SCHEMBL7677894 | 0.77 | GPR119 (0.58) | GPR119HDAC4LMNAMAPTNPC1 | |
| SCHEMBL19144654 | 0.77 | L3MBTL1 (0.53) | GPR4LMNAMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |