Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.41 |
| ▸ | SELE | P16581 | 2/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | CDC42 | P60953 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18762307 | 0.75 | MTNR1A (0.42) | MTNR1AMTNR1BATAD2NPC1RAB9A | |
| SCHEMBL18762308 | 0.75 | MTNR1A (0.42) | MTNR1AMTNR1BATAD2NPC1RAB9A | |
| SCHEMBL7070889 | 0.74 | NQO1 (0.44) | KDM4EPOLBHPGDSNPC1RAB9A | |
| SCHEMBL7071552 | 0.73 | TDP1 (0.48) | KDM4EPOLBHPGDSNPC1RAB9A | |
| SCHEMBL7135637 | 0.72 | MTNR1A (0.46) | KDM4EMTNR1AMTNR1BNPC1RAB9A | |
| SCHEMBL4695908 | 0.68 | MTNR1A (0.42) | KDM4EPOLBMTNR1AMTNR1BNPC1 | |
| SCHEMBL6270713 | 0.68 | TDP1 (0.47) | KDM4EPOLBHPGDSTDP1 | |
| SCHEMBL6047773 | 0.67 | KDM4E (0.45) | KDM4EPOLBMTNR1AMTNR1BPTGS2 | |
| SCHEMBL17582786 | 0.66 | NCF1 (0.46) | KDM4EPOLBNPC1RAB9ACYP1A2 | |
| SCHEMBL18805363 | 0.66 | ALDH1A1 (0.48) | KDM4EPOLBMTNR1AMTNR1BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030216582-A1 | 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY | NIKOLAIDES NICHOLAS (US) | 2003-11-20 | — | — | US | disclosed |
| EP-1263736-A1 | 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY | THE PROCTER & GAMBLE COMPANY (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001058878-A1 | 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY | THE PROCTER & GAMBLE COMPANY (US) | 2001-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216582-A1 | 2-CARBOXAMIDE-BENZIMIDAZOLES USEFUL IN THE TREATMENT AND PREVENTION OF ISCHEMIC REPERFUSION INJURY | CBR3, BAK1, CBR1 | KDM4E 2913/4885POLB 3479/4885HPGDS 2069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.