Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.73 |
| ▸ | MMP13 | P45452 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072174 | 0.86 | MMP2 (0.77) | MMP2MMP13MEN1KMT2ALMNA | |
| SCHEMBL5899024 | 0.84 | MMP2 (1.00) | MMP2MMP13MEN1KMT2ALMNA | |
| SCHEMBL8337431 | 0.81 | CA1 (0.58) | MEN1KMT2ALMNAPOLBHSD17B10 | |
| SCHEMBL31212417 | 0.80 | MEN1 (0.59) | MMP2MMP13MEN1KMT2ALMNA | |
| SCHEMBL31212427 | 0.80 | MEN1 (0.59) | MMP2MMP13MEN1KMT2ALMNA | |
| SCHEMBL14477864 | 0.79 | POLB (0.53) | MMP2MMP13MEN1KMT2ALMNA | |
| SCHEMBL14697013 | 0.77 | HSD17B10 (0.56) | LMNAGAAPOLBHSD17B10ALDH1A1 | |
| SCHEMBL6586759 | 0.77 | MAPT (0.60) | MMP2MMP13MEN1KMT2ALMNA | |
| SCHEMBL20435717 | 0.76 | TP53 (0.52) | MMP2MMP13MEN1KMT2ALMNA | |
| SCHEMBL7076424 | 0.75 | MMP2 (0.61) | MMP2MMP13LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |
| EP-1163213-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056704-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |