Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.61 |
| ▸ | MMP13 | P45452 | 3/20 | 0.61 |
| ▸ | ACLY | P53396 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FPR2 | P25090 | 4/20 | 0.50 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076681 | 0.88 | ACLY (0.60) | MMP2MMP13ACLYSMN1; SMN2MAPT | |
| SCHEMBL7074343 | 0.87 | MMP2 (0.76) | MMP2MMP13ACLYSMN1; SMN2MAPT | |
| SCHEMBL7072160 | 0.83 | LMNA (0.57) | HSD17B10MAPTPOLBFPR2PROKR1 | |
| SCHEMBL7079580 | 0.82 | MMP13 (0.48) | MMP2MMP13ACLYHSD17B10MAPT | |
| SCHEMBL7080602 | 0.80 | MAPT (0.65) | ACLYHSD17B10SMN1; SMN2MAPTPOLB | |
| SCHEMBL7076372 | 0.79 | ACLY (0.53) | MMP2MMP13ACLYSMN1; SMN2MAPT | |
| SCHEMBL7072306 | 0.78 | ACLY (0.57) | MMP2MMP13ACLYFPR2PROKR1 | |
| SCHEMBL7076370 | 0.78 | MMP2 (0.53) | MMP2MMP13ACLYFPR2PROKR1 | |
| SCHEMBL8363776 | 0.78 | MMP2 (0.60) | MMP2MMP13ACLYSMN1; SMN2MAPT | |
| SCHEMBL8337431 | 0.77 | CA1 (0.58) | HSD17B10SMN1; SMN2POLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |
| EP-1163213-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056704-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |