Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7071693 | 0.90 | LMNA (0.55) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7074627 | 0.84 | TSHR (0.57) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7074241 | 0.82 | HDAC4 (0.53) | HDAC4HDAC6DGAT1LMNAALOX15 | |
| SCHEMBL7074802 | 0.81 | HDAC4 (0.53) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7070577 | 0.80 | SMN1; SMN2 (0.52) | LMNATSHRMAOAMAOBKCNH2 | |
| SCHEMBL7074329 | 0.80 | MAPT (0.59) | DGAT1LMNATSHRMAPK1PLK1 | |
| SCHEMBL7069975 | 0.80 | GAA (0.60) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7651866 | 0.79 | DGAT1 (0.42) | DGAT1LMNATSHRMAPK1PLK1 | |
| SCHEMBL7076669 | 0.79 | GAA (0.53) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7074862 | 0.79 | DGAT1 (0.53) | HDAC4HDAC6DGAT1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |