Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PKLR | P30613 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070554 | 0.91 | MAPT (0.52) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL7069980 | 0.88 | TSHR (0.54) | ALDH1A1LMNASMN1; SMN2TSHRMAPT | |
| SCHEMBL7076863 | 0.87 | LSS (0.49) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL7075159 | 0.86 | LSS (0.51) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL7074071 | 0.85 | KDM4E (0.56) | ALDH1A1LMNASMN1; SMN2TSHRMAPT | |
| SCHEMBL7074179 | 0.85 | MAPT (0.74) | ALDH1A1POLBLMNASMN1; SMN2TSHR | |
| SCHEMBL7076926 | 0.84 | LSS (0.52) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL7069983 | 0.82 | LMNA (0.58) | ALDH1A1POLBLMNASMN1; SMN2MAPT | |
| SCHEMBL8003134 | 0.81 | MAPT (0.48) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8080659 | 0.81 | LMNA (0.55) | ALDH1A1POLBLMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |