Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069980 | 0.88 | TSHR (0.54) | LSSLMNAALDH1A1SMN1; SMN2CA12 | |
| SCHEMBL7076863 | 0.87 | LSS (0.49) | LSSLMNAALDH1A1POLBMAPK1 | |
| SCHEMBL7074079 | 0.86 | ALDH1A1 (0.63) | LMNAPKMHTTALDH1A1POLB | |
| SCHEMBL7074071 | 0.85 | KDM4E (0.56) | LMNAPKMHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL7073990 | 0.85 | THRB (0.56) | LMNAHTTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7076926 | 0.84 | LSS (0.52) | LSSLMNAALDH1A1POLBMAPK1 | |
| SCHEMBL7132172 | 0.82 | ALDH1A1 (0.54) | LMNAPKMHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL7070554 | 0.81 | MAPT (0.52) | LMNAHTTALDH1A1POLBMAPK1 | |
| SCHEMBL7388986 | 0.81 | ATM (0.45) | LMNAPKMHTTALDH1A1POLB | |
| SCHEMBL7384895 | 0.80 | THRB (0.44) | LMNAHTTALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |