Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.61 |
| ▸ | CFTR | P13569 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076382 | 0.88 | CCR2 (0.51) | CCR2ALDH1A1MAPTPOLBPLA2G2A | |
| SCHEMBL7071931 | 0.86 | CCR2 (0.72) | CCR2SMN1; SMN2 | |
| SCHEMBL7077284 | 0.85 | CCR2 (0.48) | CCR2LMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL6303579 | 0.84 | CCR2 (0.85) | CCR2 | |
| SCHEMBL6177863 | 0.81 | CCR2 (0.43) | CCR2LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7129310 | 0.80 | CCR2 (0.48) | CCR2CFTRALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6174275 | 0.78 | CCR2 (0.42) | CCR2KMT2AMEN1L3MBTL1 | |
| SCHEMBL8131716 | 0.78 | MAPT (0.50) | CCR2LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6173483 | 0.77 | KMT2A (0.45) | CCR2CFTRLMNAALDH1A1MAPT | |
| SCHEMBL7072404 | 0.75 | CCR2 (0.67) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | claimed |