Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14127316 | 0.87 | POLB (0.67) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| 3,4-Methylendioxy Acetophenone SCHEMBL29405437 | 0.83 | KDM4E (0.71) | MEN1KMT2AALDH1A1MAPK1SRD5A2 | |
| SCHEMBL3465063 | 0.83 | MEN1 (0.69) | MEN1KMT2AALDH1A1MAPK1SRD5A2 | |
| 3,4-Methylendioxy Acetophenone SCHEMBL137979 | 0.83 | KDM4E (0.71) | MEN1KMT2AALDH1A1MAPK1SRD5A2 | |
| SCHEMBL22745597 | 0.80 | MEN1 (0.56) | MEN1KMT2AALDH1A1MAPK1SRD5A2 | |
| SCHEMBL30848523 | 0.80 | POLB (0.80) | MEN1KMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL1463740 | 0.80 | POLB (0.80) | MEN1KMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL12745805 | 0.80 | POLB (0.80) | MEN1KMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL12930765 | 0.80 | MEN1 (0.75) | MEN1KMT2AALDH1A1MAPK1SRD5A2 | |
| SCHEMBL1463747 | 0.80 | POLB (0.80) | MEN1KMT2AALDH1A1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030176642-A1 | Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors | GYORKOS ALBERT (US) | 2003-09-18 | — | — | US | claimed |
| CN-1399632-A | Pyrimidine derivative, process for producing the same, and pharmaceutical containing the same as active ingredient | ONO PHARMACEUTICAL CO (JP) | 2003-02-26 | — | — | CN | claimed |
| EP-1219608-A1 | PYRIMIDINE DERIVATIVES, PROCESS FOR PREPARING THE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-03 | — | — | EP | claimed |
| US-20020010315-A1 | Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors | GYORKOS ALBERT (US) | 2002-01-24 | — | — | US | claimed |
| EP-1089752-A4 | ALPHA-KETO OXADIAZOLES AS SERINE PROTEASE INHIBITORS | CORTECH INC (US) | 2002-01-02 | — | — | EP | claimed |
| US-6255453-B1 | INHIBITORS OF HUMAN NEUTOPHIL ELASTASE; TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME, SEPTIC SHOCK, MULTIPLE ORGAN FAILURE, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, CYSTIC FIBROSIS; ANTIARTHRTITIC AGENTS | CORTECH, INC. | 2001-07-03 | — | — | US | claimed |
| EP-1089752-A1 | ALPHA-KETO OXADIAZOLES AS SERINE PROTEASE INHIBITORS | Cortech Inc. (US) | 2001-04-11 | — | — | EP | claimed |
| US-6001814-A | TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME, SEPSISMULTIPLE ORGAN FAILURE | CORTECH INC. (US) | 1999-12-14 | — | — | US | claimed |
| WO-1999062538-A1 | ALPHA-KETO OXADIAZOLES AS SERINE PROTEASE INHIBITORS | CORTECH INC. (US) | 1999-12-09 | — | — | WO | claimed |
| US-3952101-A | BETA ADRENERGIC STIMULANT | SMITHKLINE CORPORATION (US) | 1976-04-20 | — | — | US | claimed |
| US-6656910-B2 | Serine protease inhibitors | CORTECH, INC. | 2003-12-02 | — | — | US | disclosed |
| US-6656911-B2 | Oxadiazole ring structure peptoids which are useful as inhibitors of serine proteases | CORTECH, INC. | 2003-12-02 | — | — | US | disclosed |
| US-20030203851-A1 | Substituted oxadiazole, peptoids which are useful for treating adult respiratory distress syndrome, septic shock and myocardial ischemia-reperfusion injury | CORTECH, INC. | 2003-10-30 | — | — | US | disclosed |
| US-20030176642-A1 | Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors | GYORKOS ALBERT (US) | 2003-09-18 | — | — | US | disclosed |
| US-6608175-B2 | Oxadiazole, thiadiazoles or triazole metal derivatives reacted with an amine containing aldehyde, deprotecting, coupling with an acid and oxidizing to create substituted oxadiazole, thiadiazole or triazole peptoids | CORTECH, INC. | 2003-08-19 | — | — | US | disclosed |
| US-5998379-A | USEFUL AS INHIBITORS OF SERINE PROTEASES, IN PARTICULAR HUMAN NEUTROPHIL ELASTASE, TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME, SEPTIC SHOCK, AND MYOCARDIAL ISCHEMIA-REPERFUSION INJURY | CORTECH INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0954526-A2 | SERINE PROTEASE INHIBITORS | CORTECH, INC. (US) | 1999-11-10 | — | — | EP | disclosed |
| WO-1998024806-A2 | SUBSTITUTED OXADIAZOLE, THIADIAZOLE AND TRIAZOLE SERINE PROTEASE INHIBITORS | CORTECH, INC. (US) | 1998-06-11 | — | — | WO | disclosed |
| CN-88101155-A | The preparation of benzo benzodioxole derivatives and application thereof | — | 1988-09-28 | — | — | CN | disclosed |
| US-3952101-A | BETA ADRENERGIC STIMULANT | SMITHKLINE CORPORATION (US) | 1976-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203851-A1 | Substituted oxadiazole, peptoids which are useful for treating adult respiratory distress syndrome, septic shock and myocardial ischemia-reperfusion injury | TNNI3, PEPD, STK35 | MEN1 4653/4885KMT2A 4854/4885ALDH1A1 3371/4885 |
| US-20020010315-A1 | Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors | ELANE, SERPINB1, HPN | MEN1 4506/4885KMT2A 3904/4885ALDH1A1 2403/4885 |
| US-20030176642-A1 | Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors | ELANE, SERPINB1, HPN | MEN1 4506/4885KMT2A 3904/4885ALDH1A1 2403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.