Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12228747 | 0.86 | MAPT (0.82) | MAPTHTTNPSR1ALDH1A1POLB | |
| SCHEMBL503802 | 0.84 | POLB (0.70) | MAPTHTTNPSR1ALDH1A1POLB | |
| SCHEMBL4900211 | 0.84 | NPC1 (0.66) | MAPTHTTALDH1A1ABCG2MEN1 | |
| SCHEMBL29581343 | 0.84 | MAPT (0.68) | MAPTHTTNPSR1ALDH1A1POLB | |
| SCHEMBL885028 | 0.84 | MAPT (0.68) | MAPTHTTNPSR1ALDH1A1POLB | |
| SCHEMBL6575927 | 0.82 | MAPT (0.66) | MAPTHTTNPSR1ALDH1A1POLB | |
| SCHEMBL24001 | 0.82 | MAPT (0.66) | MAPTHTTNPSR1ALDH1A1POLB | |
| SCHEMBL1086016 | 0.82 | MAPT (0.66) | MAPTHTTNPSR1ALDH1A1POLB | |
| SCHEMBL1759671 | 0.82 | MAPT (0.66) | MAPTHTTNPSR1ALDH1A1POLB | |
| SCHEMBL9185042 | 0.82 | POLB (0.68) | MAPTHTTNPSR1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030036661-A1 | 2-Aroyl-4-acyl paclitaxel (taxol) analogs | BRISTOL-MYERS SQUIBB COMPANY | 2003-02-20 | — | — | US | claimed |
| EP-1067923-A4 | 2-AROYL-4-ACYL PACLITAXEL (TAXOL) ANALOGS | BRISTOL MYERS SQUIBB CO (US) | 2002-11-13 | — | — | EP | claimed |
| US-6391916-B1 | ANTITUMOR AGENTS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2002-05-21 | — | — | US | claimed |
| EP-1067923-A1 | 2-AROYL-4-ACYL PACLITAXEL (TAXOL) ANALOGS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-01-17 | — | — | EP | claimed |
| WO-1999033462-A9 | 2-AROYL-4-ACYL PACLITAXEL (TAXOL) ANALOGS | KINGSTON DAVID GEORGE IAN (US) | 1999-09-30 | — | — | WO | claimed |
| WO-1999033462-A1 | 2-AROYL-4-ACYL PACLITAXEL (TAXOL) ANALOGS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 1999-07-08 | — | — | WO | claimed |
| US-20030036661-A1 | 2-Aroyl-4-acyl paclitaxel (taxol) analogs | BRISTOL-MYERS SQUIBB COMPANY | 2003-02-20 | — | — | US | disclosed |
| EP-1067923-A4 | 2-AROYL-4-ACYL PACLITAXEL (TAXOL) ANALOGS | BRISTOL MYERS SQUIBB CO (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6476242-B1 | 2-aroyl-4-acyl paclitaxel (Taxol) analogs | BRISTOL-MYERS SQUIBB COMPANY | 2002-11-05 | — | — | US | disclosed |
| US-6391916-B1 | ANTITUMOR AGENTS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2002-05-21 | — | — | US | disclosed |
| EP-1067923-A1 | 2-AROYL-4-ACYL PACLITAXEL (TAXOL) ANALOGS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999033462-A9 | 2-AROYL-4-ACYL PACLITAXEL (TAXOL) ANALOGS | KINGSTON DAVID GEORGE IAN (US) | 1999-09-30 | — | — | WO | disclosed |
| WO-1999033462-A1 | 2-AROYL-4-ACYL PACLITAXEL (TAXOL) ANALOGS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 1999-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036661-A1 | 2-Aroyl-4-acyl paclitaxel (taxol) analogs | HDAC6, HDAC3, ACAT2 | MAPT 543/4885HTT 857/4885NPSR1 4045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.