Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 15/20 | 0.46 |
| ▸ | METAP1 | P53582 | 8/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6477553 | 0.77 | METAP2 (0.58) | METAP2METAP1EPHX2 | |
| SCHEMBL6487354 | 0.71 | METAP2 (0.69) | METAP2METAP1 | |
| SCHEMBL6934858 | 0.70 | METAP2 (0.46) | METAP2METAP1EPHX2MEN1KMT2A | |
| SCHEMBL6476898 | 0.67 | METAP2 (0.66) | METAP2METAP1REN | |
| SCHEMBL8128756 | 0.66 | METAP2 (0.49) | METAP2METAP1REN | |
| SCHEMBL6563124 | 0.66 | METAP2 (0.50) | METAP2METAP1KMT2A | |
| SCHEMBL10408952 | 0.66 | METAP2 (0.55) | METAP2METAP1REN | |
| SCHEMBL6486250 | 0.66 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL7357994 | 0.66 | METAP2 (0.46) | METAP2METAP1REN | |
| SCHEMBL6940184 | 0.65 | METAP2 (0.49) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | disclosed |