Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 13/20 | 0.46 |
| ▸ | METAP1 | P53582 | 8/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563124 | 0.79 | METAP2 (0.50) | METAP2METAP1KMT2ANPC1RAB9A | |
| SCHEMBL6940184 | 0.78 | METAP2 (0.49) | METAP2METAP1ATMNPC1RAB9A | |
| SCHEMBL6488721 | 0.75 | METAP2 (0.72) | METAP2METAP1L3MBTL1MEN1ALDH1A1 | |
| SCHEMBL6565227 | 0.74 | METAP2 (0.50) | METAP2METAP1L3MBTL1ALDH1A1POLB | |
| SCHEMBL6561605 | 0.72 | METAP2 (0.64) | METAP2METAP1ALDH1A1PYGLTSHR | |
| SCHEMBL6564663 | 0.71 | METAP2 (0.50) | METAP2METAP1NPC1TSHRRAB9A | |
| SCHEMBL7074866 | 0.70 | METAP2 (0.46) | METAP2METAP1MEN1KMT2AEPHX2 | |
| SCHEMBL7312595 | 0.70 | METAP2 (0.62) | METAP2METAP1MEN1KMT2AATM | |
| SCHEMBL6564599 | 0.70 | METAP2 (0.64) | METAP2METAP1L3MBTL1NPC1RAB9A | |
| SCHEMBL6563343 | 0.69 | METAP2 (0.46) | METAP2METAP1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | claimed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | claimed |