Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 14/20 | 0.49 |
| ▸ | METAP1 | P53582 | 8/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PTGIR | P43119 | 2/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476574 | 0.80 | METAP2 (0.50) | METAP2METAP1 | |
| SCHEMBL6563124 | 0.79 | METAP2 (0.50) | METAP2METAP1NPC1RAB9A | |
| SCHEMBL6934858 | 0.78 | METAP2 (0.46) | METAP2METAP1ATMNPC1RAB9A | |
| SCHEMBL6565227 | 0.76 | METAP2 (0.50) | METAP2METAP1PTGIRCTSS | |
| SCHEMBL6491205 | 0.74 | METAP2 (0.65) | METAP2METAP1NPC1RAB9A | |
| SCHEMBL6476489 | 0.73 | METAP2 (0.77) | METAP2METAP1 | |
| SCHEMBL6564589 | 0.73 | METAP2 (0.49) | METAP2METAP1ATM | |
| SCHEMBL7353505 | 0.73 | METAP2 (0.59) | METAP2METAP1 | |
| SCHEMBL6476581 | 0.72 | METAP2 (0.57) | METAP2METAP1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7361580 | 0.72 | METAP2 (0.58) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | claimed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | claimed |