Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7075715 | 0.93 | KDM4E (0.43) | KDM4ETDP1L3MBTL1MAOAMAOB | |
| SCHEMBL7130108 | 0.88 | KDM4E (0.43) | KDM4ETDP1L3MBTL1HDAC1HDAC2 | |
| SCHEMBL7136554 | 0.86 | ALDH1A1 (0.50) | KDM4ETDP1L3MBTL1MAOAMAOB | |
| SCHEMBL7075691 | 0.85 | MAPT (0.47) | KDM4ETDP1L3MBTL1HDAC1HDAC2 | |
| SCHEMBL7076016 | 0.85 | KDM4E (0.49) | KDM4ETDP1L3MBTL1MAOAMAOB | |
| SCHEMBL7076583 | 0.84 | KDM4E (0.48) | KDM4ETDP1L3MBTL1MAOBMAPT | |
| SCHEMBL7135585 | 0.79 | BACE1 (0.56) | KDM4EKMT2AALDH1A1 | |
| SCHEMBL7075963 | 0.74 | ALDH1A1 (0.55) | KDM4EMAOAMAOBMAPTDHODH | |
| SCHEMBL7130579 | 0.74 | CA12 (0.46) | KDM4ETDP1L3MBTL1MAPTRAB9A | |
| SCHEMBL31155867 | 0.74 | ALDH1A1 (0.55) | SMPD1MAPTRAB9AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051368-A1 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-26 | — | — | WO | disclosed |