Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074931 | 0.93 | KDM4E (0.44) | KDM4ETDP1L3MBTL1MAPTDHODH | |
| SCHEMBL7130108 | 0.88 | KDM4E (0.43) | KDM4ETDP1L3MBTL1MAPTDHODH | |
| SCHEMBL7076583 | 0.86 | KDM4E (0.48) | KDM4ETDP1L3MBTL1MAPTMAOB | |
| SCHEMBL7076016 | 0.85 | KDM4E (0.49) | KDM4ETDP1L3MBTL1MAPTMAOA | |
| SCHEMBL7136554 | 0.84 | ALDH1A1 (0.50) | KDM4ETDP1L3MBTL1MAPTMAOA | |
| SCHEMBL7135585 | 0.81 | BACE1 (0.56) | KDM4EALDH1A1MEN1GAAKMT2A | |
| SCHEMBL7075691 | 0.78 | MAPT (0.47) | KDM4ETDP1L3MBTL1MAPTLMNA | |
| SCHEMBL7130579 | 0.76 | CA12 (0.46) | KDM4ETDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL5949785 | 0.75 | ALDH1A1 (0.50) | KDM4ETDP1L3MBTL1MAPTALDH1A1 | |
| SCHEMBL1606555 | 0.74 | MAPT (0.54) | MAPTALDH1A1RAB9AKMT2ACYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051368-A1 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-26 | — | — | WO | disclosed |