Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308298 | 0.80 | PLA2G10 (0.39) | DRD2KDM4EPOLBSMN1; SMN2CCKBR | |
| SCHEMBL19984920 | 0.70 | MTNR1A (0.47) | MTNR1B | |
| SCHEMBL30492989 | 0.68 | NAMPT (0.43) | DRD2KDM4EALDH1A1 | |
| SCHEMBL5879532 | 0.68 | KDR (0.37) | ALDH1A1HDAC3HDAC1HDAC8 | |
| SCHEMBL12312034 | 0.67 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL23926172 | 0.66 | HDAC8 (0.48) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL29763648 | 0.66 | HDAC8 (0.48) | HDAC3HDAC1HDAC2HDAC8NCOR2 | |
| SCHEMBL27761216 | 0.66 | NOTUM (0.57) | ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4849847 | 0.65 | MTNR1B (0.45) | MTNR1BDRD2 | |
| SCHEMBL8523119 | 0.65 | BCAT2 (0.46) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268429-A1 | VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001079172-A1 | VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER Departament Brevets/Fontanes (FR) | 2001-10-25 | — | — | WO | disclosed |