Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | LSS | P48449 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070020 | 0.91 | MAPT (0.59) | THRBMAPTPOLBHSD11B1MEN1 | |
| SCHEMBL7073990 | 0.89 | THRB (0.56) | THRBMAPTPOLBMEN1KMT2A | |
| SCHEMBL7071891 | 0.89 | THRB (0.63) | THRBMAPTPOLBMEN1KMT2A | |
| SCHEMBL7074179 | 0.87 | MAPT (0.74) | THRBMAPTPOLBHSD11B1MEN1 | |
| SCHEMBL7071433 | 0.86 | MAPT (0.62) | THRBMAPTPOLBMEN1KMT2A | |
| SCHEMBL7070226 | 0.85 | THRB (0.54) | THRBMAPTPOLBHSD11B1MEN1 | |
| SCHEMBL7074028 | 0.84 | MAPT (0.62) | THRBMAPTPOLBMEN1KMT2A | |
| SCHEMBL7071746 | 0.84 | MEN1 (0.54) | POLBMEN1KMT2ALMNAHTT | |
| SCHEMBL7389136 | 0.81 | SIGMAR1 (0.46) | THRBMAPTPOLBLMNALSS | |
| SCHEMBL7655621 | 0.81 | LMNA (0.57) | MAPTPOLBMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |