Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.49 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.49 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076620 | 0.86 | TSHR (0.57) | ALDH1A1TSHRPLGSMN1; SMN2GLA | |
| SCHEMBL7072198 | 0.85 | F2 (0.53) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7074218 | 0.81 | ALDH1A1 (0.67) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7075147 | 0.79 | RAB9A (0.60) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7074652 | 0.78 | F2 (0.54) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7070008 | 0.78 | GAA (0.56) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7070571 | 0.78 | GAA (0.58) | F2PRSS1TPSAB1TPSD1TPSG1 | |
| SCHEMBL7074575 | 0.77 | HDAC4 (0.48) | ALDH1A1TSHRSMN1; SMN2LMNAJAK1 | |
| SCHEMBL7074671 | 0.76 | F2 (0.56) | F2PRSS1PLGITGB3ITGA2B | |
| SCHEMBL7074851 | 0.75 | GAA (0.63) | F2PRSS1TPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |