Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080502 | 0.89 | LMNA (0.44) | DGAT1SPHK2LMNATSHRALDH1A1 | |
| SCHEMBL7077520 | 0.87 | LMNA (0.54) | HDAC4HDAC6LMNATSHRNPC1 | |
| SCHEMBL7074627 | 0.84 | TSHR (0.57) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7074862 | 0.83 | DGAT1 (0.53) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7074802 | 0.81 | HDAC4 (0.53) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7071584 | 0.81 | GAA (0.52) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7076669 | 0.81 | GAA (0.53) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7069975 | 0.80 | GAA (0.60) | HDAC4HDAC6DGAT1LMNATSHR | |
| SCHEMBL7075151 | 0.78 | HDAC4 (0.49) | HDAC4HDAC6DGAT1LMNANPC1 | |
| SCHEMBL7074530 | 0.78 | THRB (0.52) | DGAT1LMNANPC1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |