Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 10/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489141 | 0.86 | CCR2 (0.60) | CCR2GPR35TRAP1 | |
| SCHEMBL6302551 | 0.85 | CCR2 (0.60) | CCR2TRAP1SLC22A12 | |
| SCHEMBL6306908 | 0.85 | CCR2 (0.60) | CCR2ALDH1A1 | |
| SCHEMBL7465471 | 0.83 | SRD5A2 (0.54) | CCR2EDNRBEDNRA | |
| SCHEMBL7464523 | 0.82 | CCR2 (0.48) | CCR2GPR35 | |
| SCHEMBL8388354 | 0.81 | CCR2 (0.48) | CCR2MCL1EDNRBEDNRA | |
| SCHEMBL7469052 | 0.81 | CCR2 (0.48) | CCR2MCL1EDNRBEDNRA | |
| SCHEMBL3966109 | 0.81 | CCR2 (0.78) | CCR2ALDH1A1CYP1A2POLBMCL1 | |
| SCHEMBL7498811 | 0.81 | CCR2 (0.49) | CCR2ALDH1A1 | |
| SCHEMBL3963211 | 0.80 | CCR2 (0.73) | CCR2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | disclosed |