Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8388354 | 1.00 | CCR2 (0.48) | CCR2ABCB11S1PR5S1PR1PLA2G4A | |
| SCHEMBL7470926 | 0.87 | CCR2 (0.44) | CCR2ABCB11S1PR5S1PR1PLA2G4A | |
| SCHEMBL7473359 | 0.87 | CCR2 (0.44) | CCR2ABCB11S1PR5S1PR1PLA2G4A | |
| SCHEMBL7465471 | 0.83 | SRD5A2 (0.54) | CCR2ABCB11S1PR5S1PR1PLA2G4A | |
| SCHEMBL7461617 | 0.82 | CCR2 (0.41) | CCR2ABCB11PLA2G4A | |
| SCHEMBL7076142 | 0.81 | CCR2 (0.60) | CCR2EDNRBEDNRAMCL1 | |
| SCHEMBL7466879 | 0.81 | EDNRB (0.48) | CCR2ABCB11PLA2G4AEDNRBEDNRA | |
| SCHEMBL7472885 | 0.81 | CCR2 (0.48) | CCR2ABCB11S1PR5S1PR1PLA2G4A | |
| SCHEMBL7455739 | 0.79 | CCR2 (0.57) | CCR2ABCB11PLA2G4AEDNRBEDNRA | |
| SCHEMBL7489141 | 0.79 | CCR2 (0.60) | CCR2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021181-A4 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORP (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1021181-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997035572-A1 | CARBOXYLIC ACID INDOLE INHIBITORS OF CHEMOKINES | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |