Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072870 | 0.91 | HTT (0.58) | HTTALDH1A1TSHRHPGDOPRK1 | |
| SCHEMBL7076508 | 0.89 | HTT (0.52) | HTTALDH1A1TSHRHPGDOPRK1 | |
| SCHEMBL7073805 | 0.82 | CA9 (0.58) | HTTALDH1A1TSHRLMNA | |
| SCHEMBL8413524 | 0.78 | HTT (0.65) | HTTALDH1A1TSHROPRK1LMNA | |
| SCHEMBL7076474 | 0.77 | TP53 (0.50) | ALDH1A1TSHRHPGDNPC1LMNA | |
| SCHEMBL15461583 | 0.75 | ALDH1A1 (0.57) | HTTALDH1A1TSHRLMNAKMT2A | |
| SCHEMBL7363401 | 0.75 | ALDH1A1 (0.57) | HTTALDH1A1TSHRLMNAKMT2A | |
| SCHEMBL22230464 | 0.75 | HTT (0.65) | HTTALDH1A1TSHRLMNA | |
| SCHEMBL27990044 | 0.74 | HTT (0.53) | HTTALDH1A1TSHRHPGDNPC1 | |
| SCHEMBL2884550 | 0.74 | ALDH1A1 (0.55) | HTTALDH1A1TSHRLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |
| EP-1163213-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056704-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |