Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 9/20 | 0.52 |
| ▸ | MMP9 | P14780 | 7/20 | 0.52 |
| ▸ | MMP8 | P22894 | 5/20 | 0.52 |
| ▸ | MMP12 | P39900 | 5/20 | 0.52 |
| ▸ | MMP2 | P08253 | 4/20 | 0.52 |
| ▸ | MMP14 | P50281 | 4/20 | 0.52 |
| ▸ | MMP16 | P51512 | 4/20 | 0.52 |
| ▸ | MMP1 | P03956 | 6/20 | 0.49 |
| ▸ | MMP3 | P08254 | 3/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076482 | 0.89 | HTT (0.56) | HTTHPGDALDH1A1OPRK1TSHR | |
| SCHEMBL7072870 | 0.88 | HTT (0.58) | HTTSLC6A5HPGDALDH1A1OPRK1 | |
| SCHEMBL7072113 | 0.81 | MMP2 (0.63) | HTTMMP13MMP9MMP8MMP12 | |
| SCHEMBL5898955 | 0.81 | MMP9 (0.62) | MMP13MMP9MMP8MMP12MMP2 | |
| SCHEMBL7076512 | 0.77 | MMP9 (0.53) | MMP13MMP9MMP8MMP12MMP2 | |
| SCHEMBL8413524 | 0.75 | HTT (0.65) | HTTALDH1A1OPRK1TSHR | |
| SCHEMBL25839479 | 0.74 | HPGD (0.68) | HTTSLC6A5HPGDALDH1A1 | |
| SCHEMBL7076489 | 0.73 | MMP12 (0.68) | HTTMMP13MMP9MMP8MMP12 | |
| SCHEMBL22230464 | 0.72 | HTT (0.65) | HTTALDH1A1TSHR | |
| SCHEMBL27811168 | 0.71 | TSHR (0.73) | HTTHPGDALDH1A1OPRK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | claimed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | claimed |
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |