Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072875 | 0.89 | L3MBTL1 (0.48) | TP53KMT2AL3MBTL1LMNAMEN1 | |
| SCHEMBL7076512 | 0.88 | MMP9 (0.53) | L3MBTL1MMP1MMP9MMP13ADAM17 | |
| SCHEMBL646787 | 0.81 | L3MBTL1 (0.54) | KDM4EKMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL7073806 | 0.78 | CA1 (0.52) | TP53KDM4EKMT2AL3MBTL1LMNA | |
| SCHEMBL7076482 | 0.77 | HTT (0.56) | KMT2ALMNAALDH1A1MEN1NPC1 | |
| SCHEMBL7363401 | 0.73 | ALDH1A1 (0.57) | KDM4EKMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL15461583 | 0.73 | ALDH1A1 (0.57) | KDM4EKMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL4880583 | 0.72 | CA1 (0.58) | KDM4EKMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL2884550 | 0.72 | ALDH1A1 (0.55) | KDM4EKMT2AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL13127059 | 0.71 | ALDH1A1 (0.40) | KDM4EKMT2AL3MBTL1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | disclosed |
| EP-1163213-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | Darwin Discovery Limited (GB) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056704-A1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES | DARWIN DISCOVERY LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |