Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 9/20 | 0.52 |
| ▸ | CA2 | P00918 | 9/20 | 0.52 |
| ▸ | CA9 | Q16790 | 8/20 | 0.52 |
| ▸ | CA5A | P35218 | 3/20 | 0.52 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16710174 | 0.75 | CA1 (0.46) | CA1CA2CA9CA5ASOS1 | |
| Methanesulfonamide SCHEMBL28058380 | 0.71 | KIF11 (0.49) | CA1CA2CA9CA5ASOS1 | |
| Phenyldifluoromethanesulfonamide SCHEMBL187768 | 0.69 | CA1 (1.00) | CA1CA2CA9CA5ACA12 | |
| SCHEMBL10477060 | 0.68 | CA4 (0.43) | CA1CA2CA9ALDH1A1TSHR | |
| SCHEMBL17968475 | 0.68 | MAPT (0.46) | CA1CA2CA9CA5AALDH1A1 | |
| SCHEMBL14104986 | 0.67 | CA1 (0.41) | CA1CA2CA9CA5ASOS1 | |
| SCHEMBL3528955 | 0.67 | NR3C1 (0.47) | CA1CA2CA9CETPKIF11 | |
| SCHEMBL6238670 | 0.67 | CA1 (0.42) | CA1CA2CA9CA5ASOS1 | |
| SCHEMBL8589920 | 0.66 | TSHR (0.48) | CA1CA2CA9CA5ACETP | |
| Trifluoromethylbenzene SCHEMBL27721404 | 0.66 | TSHR (0.70) | CA1CA2CA9CA5ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268396-A1 | DIPHENYL ETHER COMPOUNDS USEFUL IN THERAPY | Pfizer Limited (GB) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072687-A1 | DIPHENYL ETHER COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2001-10-04 | — | — | WO | disclosed |