Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7079945 | 0.86 | DRD2 (0.35) | RENCHRM3BACE1BACE2 | |
| SCHEMBL6041824 | 0.85 | RAB9A (0.36) | RENCHRM3 | |
| SCHEMBL7079543 | 0.84 | REN (0.39) | REN | |
| SCHEMBL7080773 | 0.83 | REN (0.51) | REN | |
| SCHEMBL7079990 | 0.83 | REN (0.38) | REN | |
| SCHEMBL7082322 | 0.82 | REN (0.33) | RENTACR1 | |
| SCHEMBL7079178 | 0.82 | REN (0.33) | RENTACR1 | |
| SCHEMBL7077071 | 0.82 | REN (0.34) | RENTACR1 | |
| SCHEMBL7076694 | 0.81 | REN (0.42) | REN | |
| SCHEMBL7080964 | 0.80 | REN (0.31) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |