Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | KDM5A | P29375 | 5/20 | 0.45 |
| ▸ | CHUK | O15111 | 8/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085913 | 0.73 | ADORA3 (1.00) | ADORA3ADORA2AADORA1KDM5ACHUK | |
| SCHEMBL31060553 | 0.73 | ADORA3 (1.00) | ADORA3ADORA2AADORA1KDM5ACHUK | |
| SCHEMBL7082459 | 0.73 | ADORA3 (0.57) | ADORA3ADORA2AADORA1KDM5ACHUK | |
| SCHEMBL30322777 | 0.70 | CHUK (0.78) | ADORA3ADORA2AADORA1KDM5ACHUK | |
| SCHEMBL12396541 | 0.70 | CHUK (0.78) | ADORA3ADORA2AADORA1KDM5ACHUK | |
| SCHEMBL9427509 | 0.68 | IMPDH2 (0.62) | ADORA3ADORA2AADORA1KDM5ACHUK | |
| SCHEMBL7082174 | 0.68 | ADORA3 (0.60) | ADORA3ADORA2AKDM5A | |
| SCHEMBL4822655 | 0.67 | KIF11 (0.58) | ADORA3ADORA2AADORA1KDM5ACHUK | |
| SCHEMBL6300717 | 0.67 | ADORA3 (0.61) | ADORA3ADORA2AADORA1KDM5ACHUK | |
| SCHEMBL2465165 | 0.66 | CHUK (0.50) | ADORA3ADORA2AADORA1KDM5ACHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030148259-A1 | Method of identifying insulin secretion stimulating compounds, and the use of such compounds in treating insulin-secretion related disorders | KAROLINSKA INNOVATIONS AB (SE) | 2003-08-07 | — | — | US | claimed |
| WO-2003065036-A1 | METHOD OF IDENTIFYING INSULIN SECRETION STIMULATING COMPOUNDS, AND THE USE OF SUCH COMPOUNDS IN TREATING INSULIN-SECRETION RELATED DISORDERS | KAROLINSKA INNOVATIONS AB (SE) | 2003-08-07 | — | — | WO | claimed |
| US-20030148259-A1 | Method of identifying insulin secretion stimulating compounds, and the use of such compounds in treating insulin-secretion related disorders | KAROLINSKA INNOVATIONS AB (SE) | 2003-08-07 | — | — | US | disclosed |
| WO-2003065036-A1 | METHOD OF IDENTIFYING INSULIN SECRETION STIMULATING COMPOUNDS, AND THE USE OF SUCH COMPOUNDS IN TREATING INSULIN-SECRETION RELATED DISORDERS | KAROLINSKA INNOVATIONS AB (SE) | 2003-08-07 | — | — | WO | disclosed |