Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6680355 | 0.80 | HSD11B1 (0.35) | HSD11B1CYP3A4KDM4EKMT2AALDH1A1 | |
| SCHEMBL6682838 | 0.80 | HSD11B1 (0.38) | HSD11B1CYP3A4KDM4EKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6680114 | 0.78 | HSD11B1 (0.34) | HSD11B1CYP3A4KDM4EKMT2AALDH1A1 | |
| SCHEMBL7081997 | 0.77 | GRIN2D (0.38) | HSD11B1CYP3A4KDM4EKMT2AALDH1A1 | |
| SCHEMBL7079611 | 0.77 | P2RX7 (0.36) | KDM4EKMT2AALDH1A1HPGDTSHR | |
| Hydrochloric Acid SCHEMBL7081992 | 0.76 | GRIN2D (0.37) | HSD11B1CYP3A4KDM4EKMT2A | |
| SCHEMBL6680311 | 0.76 | HSD11B1 (0.34) | HSD11B1CYP3A4KDM4EKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6686059 | 0.75 | KMT2A (0.34) | HSD11B1CYP3A4KDM4EKMT2AALDH1A1 | |
| SCHEMBL6682527 | 0.73 | LMNA (0.38) | HSD11B1CYP3A4KDM4EKMT2AALDH1A1 | |
| SCHEMBL6683844 | 0.72 | MEN1 (0.38) | HSD11B1KMT2AALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003064372-A1 | 2-ADAMANTYLALKYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2003-08-07 | — | — | WO | disclosed |