Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTR1E | P28566 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080287 | 0.85 | HSD11B1 (0.52) | FBP1HSD11B1ALDH1A1KMT2AMEN1 | |
| SCHEMBL7082944 | 0.85 | HSD11B1 (0.51) | FBP1HSD11B1KMT2AMEN1 | |
| SCHEMBL7082940 | 0.85 | HSD11B1 (0.51) | FBP1HSD11B1KMT2AMEN1 | |
| SCHEMBL7079469 | 0.83 | FBP1 (0.44) | FBP1HSD11B1MAOAMAOB | |
| SCHEMBL7083527 | 0.78 | HSD11B1 (0.42) | HSD11B1LMNANPSR1KMT2AMEN1 | |
| SCHEMBL7082452 | 0.78 | HSD11B1 (0.39) | HSD11B1ALDH1A1KMT2AMEN1 | |
| SCHEMBL7079599 | 0.78 | HSD11B1 (0.52) | FBP1HSD11B1LMNAMAPTNPSR1 | |
| SCHEMBL6685193 | 0.74 | HTR2C (0.46) | HSD11B1KMT2AMEN1HTR2CHTR2A | |
| SCHEMBL7083812 | 0.73 | HSD11B1 (0.33) | HSD11B1 | |
| SCHEMBL7083810 | 0.73 | HSD11B1 (0.33) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003064372-A1 | 2-ADAMANTYLALKYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2003-08-07 | — | — | WO | disclosed |