Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972343 | 0.93 | IDO1 (0.36) | IDO1GRM2RORCNAMPTKDM4E | |
| SCHEMBL7082209 | 0.90 | IDO1 (0.34) | IDO1GRM2RORCNAMPTKDM4E | |
| SCHEMBL6973278 | 0.89 | MEN1 (0.35) | IDO1RORCNAMPTKDM4EHSD17B10 | |
| SCHEMBL6969311 | 0.89 | LMNA (0.37) | IDO1NAMPTKDM4EHSD17B10TBXAS1 | |
| SCHEMBL6973902 | 0.87 | IDO1 (0.32) | IDO1GRM2RORC | |
| SCHEMBL6967430 | 0.86 | ALDH1A1 (0.41) | IDO1RORCKDM4EKMT2A | |
| SCHEMBL6969546 | 0.86 | IDO1 (0.36) | IDO1GRM2RORCNAMPTKDM4E | |
| SCHEMBL6973462 | 0.84 | ALDH1A1 (0.32) | IDO1 | |
| SCHEMBL6960778 | 0.83 | LMNA (0.34) | IDO1GRM2NAMPTKMT2ACYP3A4 | |
| SCHEMBL6972999 | 0.83 | RXFP1 (0.37) | KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |