Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | S100B | P04271 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL526857 | 0.96 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1CYP3A4TSHRGFER | |
| Hydrochloric Acid SCHEMBL9820908 | 0.94 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1CYP3A4TSHRGFER | |
| Hydrochloric Acid SCHEMBL30338656 | 0.94 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1CYP3A4TSHRGFER | |
| Hydrochloric Acid SCHEMBL3336490 | 0.94 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1CYP3A4TSHRGFER | |
| Water SCHEMBL7079816 | 0.91 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1CYP3A4TSHRGFER | |
| Water SCHEMBL7079818 | 0.89 | S100B (0.49) | ALDH1A1L3MBTL1CYP3A4TSHRGFER | |
| Sulfuric Acid SCHEMBL7120165 | 0.86 | GAA (0.45) | ALDH1A1L3MBTL1CYP3A4TSHRGFER | |
| SCHEMBL29564357 | 0.82 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1CYP3A4TSHRGFER | |
| SCHEMBL6565275 | 0.82 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1CYP3A4TSHRGFER | |
| SCHEMBL15263534 | 0.80 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1CYP3A4TSHRGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656672-B2 | Imaging element containing incorporated photographically useful compounds | EASTMAN KODAK COMPANY | 2003-12-02 | — | — | US | disclosed |
| US-20030148233-A1 | IMAGING ELEMENT CONTAINING INCORPORATED PHOTOGRAPHICALLY USEFUL COMPOUNDS | EASTMAN KODAK COMPANY | 2003-08-07 | — | — | US | disclosed |
| EP-1324119-A1 | Imaging element containing incorporated photographically useful compounds | EASTMAN KODAK COMPANY (US) | 2003-07-02 | — | — | EP | disclosed |