Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 14/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 13/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 12/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7073107 | 0.92 | ADRB3 (0.51) | LMNAMEN1KMT2AKDM4EMITF | |
| SCHEMBL7560376 | 0.85 | LMNA (0.56) | LMNAMEN1KMT2AKDM4EMITF | |
| SCHEMBL7836521 | 0.80 | LMNA (0.53) | LMNAMEN1KMT2AKDM4EMITF | |
| SCHEMBL7460733 | 0.77 | LMNA (0.52) | LMNAMEN1KMT2AKDM4EMITF | |
| SCHEMBL7469004 | 0.76 | ADRB3 (0.52) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7473044 | 0.76 | ADRB3 (0.52) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7470650 | 0.75 | LMNA (0.46) | LMNAMEN1KMT2AKDM4EMITF | |
| SCHEMBL7461831 | 0.75 | LMNA (0.46) | LMNAMEN1KMT2AKDM4EMITF | |
| SCHEMBL7461019 | 0.75 | PIK3CA (0.52) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7467859 | 0.75 | LMNA (0.45) | LMNAMEN1KMT2AKDM4EMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649627-B1 | N-Substituted with 1- (pyrid-2-yl)-piperidine-4-yl radical; gastrointestinal and psychological disorder treatment; antidiabetic tocolytic, and antidepressant agents; irritable bowel syndrome, glaucoma and dysmenorrhoea | SANOFI-SYNTHELABO (FR) | 2003-11-18 | — | — | US | disclosed |
| EP-1087961-B1 | PHENOXYLPROPANOLAMINES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SANOFI SYNTHELABO (FR) | 2002-08-14 | — | — | EP | disclosed |