Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MGAT2 | Q10469 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 5/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | MGAT1 | P26572 | 1/20 | 0.34 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954313 | 0.71 | ALDH1A1 (0.60) | MEN1KMT2AMAPK1 | |
| SCHEMBL6949092 | 0.69 | HTR2C (0.54) | PKLRTP53PARGMEN1KMT2A | |
| SCHEMBL30555219 | 0.69 | PKLR (0.55) | PKLRIDO1GAAMGAT2TP53 | |
| SCHEMBL6954051 | 0.69 | PKLR (0.55) | PKLRIDO1GAAMGAT2TP53 | |
| SCHEMBL6943633 | 0.68 | ALDH1A1 (0.58) | PKLRIDO1GAATP53MEN1 | |
| SCHEMBL2582634 | 0.68 | PKLR (1.00) | PKLRGAATP53POLB | |
| SCHEMBL6954598 | 0.67 | GAA (0.63) | GAAMEN1POLBKMT2A | |
| SCHEMBL6947705 | 0.67 | GAA (0.62) | GAAMEN1POLBKMT2A | |
| SCHEMBL6951305 | 0.67 | MGAT2 (0.60) | PKLRMGAT2TP53POLB | |
| SCHEMBL6950254 | 0.67 | PKLR (0.50) | PKLRIDO1GAAMGAT2PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988035-B1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |