SCHEMBL7081176

SCHEMBL7081176

[Si]c1ccccc1-c1cc(Cl)c(Cl)c(Cl)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
AHR P35869 7/20 0.45
CYP3A4 P08684 2/20 0.40
HSP90AA1 P07900 2/20 0.34
HSP90AB1 P08238 1/20 0.34
TSHR P16473 2/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
CYP2A6 P11509 1/20 0.32
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4459798 0.80 AHR (0.50) AHRCYP3A4HSP90AA1HSP90AB1TSHR
SCHEMBL30034845 0.76 CYP3A4 (0.67) AHRCYP3A4HSP90AA1TSHRHPGD
SCHEMBL2230314 0.76 CYP3A4 (0.67) AHRCYP3A4HSP90AA1TSHRHPGD
SCHEMBL7604144 0.75 HPGD (0.48) AHRCYP3A4HSP90AA1HSP90AB1TSHR
SCHEMBL28795908 0.75 ALDH1A1 (0.54) AHRCYP3A4HSP90AA1HSP90AB1TSHR
SCHEMBL30444732 0.74 AHR (0.48) AHRCYP3A4HSP90AA1TSHRHPGD
SCHEMBL4453591 0.74 AHR (0.48) AHRCYP3A4HSP90AA1TSHRHPGD
SCHEMBL29422942 0.71 AHR (0.68) AHRCYP3A4HSP90AA1TSHRHPGD
SCHEMBL404196 0.71 AHR (0.68) AHRCYP3A4HSP90AA1TSHRHPGD
SCHEMBL29450677 0.70 AHR (0.62) AHRCYP3A4HSP90AA1TSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0128721-B1 SILICA-MODIFIED CATALYST AND USE FOR SELECTIVE PRODUCTION OF PARA-DIALKYL SUBSTITUTED BENZENES MOBIL OIL CORPORATION (US) 1989-07-26 EP claimed
WO-2003059508-A1 REFORMING CATALYST AND PROCESS EXXONMOBIL CHEMICAL PATENTS INC. (US) 2003-07-24 WO disclosed
US-20030136708-A1 Reforming catalyst and process EXXONMOBIL RESEARCH & ENGINEERING CO. 2003-07-24 US disclosed
US-6541408-B2 Progressive temperature gradient stabilizes hydrorefining catalysts (metal-modified zeolite) to allow long duration of use and low by-product make EXXONMOBIL OIL CORP. 2003-04-01 US disclosed
US-20020091293-A1 Zeolite catalysts having stabilized hydrogenation-dehydrogenation function EXXONMOBIL OIL CORPORATION 2002-07-11 US disclosed
US-6346498-B1 PERMEATING METAL INTO MOLECULAR SIEVE; IN SITU SELECTIVATION WITH SILICON COMPOUND AND ROASTING; BY-PRODUCT INHIBITION EXXONMOBIL OIL CORPORATION 2002-02-12 US disclosed
US-6207871-B1 CONVERTING A HYDROCARBON FEEDSTREAM COMPRISING ETHYLBENZENE AND META-XYLENE OVER MOLECULAR SIEVE CATALYST UNDER ETHYLBENZENE CONVERSION CONDITIONS, MOBIL OIL CORPORATION 2001-03-27 US disclosed
US-4532368-A Passing mixture of phenol, ortho-alkylphenol, alkylating agent through zeolite catalyst, separating and recycling ortho-alkylphenols ETHYL CORPORATION (US) 1985-07-30 US disclosed
US-4444989-A Methylation of toluene to para-xylene catalyzed by crystalline silica E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-24 US disclosed
US-4283306-A CATALYTIC METHYLATION OF TOLUENE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-08-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020091293-A1 Zeolite catalysts having stabilized hydrogenation-dehydrogenation function HDHD5, HSF1, HRH4 AHR 10/4885CYP3A4 62/4885HSP90AA1 147/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.