Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.57 |
| ▸ | DRD4 | P21917 | 9/20 | 0.56 |
| ▸ | DRD3 | P35462 | 9/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | HTR2C | P28335 | 4/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 7/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR1E | P28566 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6956800 | 0.99 | HTR1A (0.56) | HTR1ADRD4DRD3HTR2AHTR2C | |
| SCHEMBL7082241 | 0.88 | SIGMAR1 (0.52) | HTR1ADRD4DRD3SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL6956636 | 0.87 | DRD2 (0.52) | HTR1ADRD4DRD3SIGMAR1DRD2 | |
| SCHEMBL7080017 | 0.86 | DRD2 (0.58) | HTR1ADRD4DRD3SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL6957049 | 0.85 | DRD2 (0.57) | HTR1ADRD4DRD3SIGMAR1DRD2 | |
| SCHEMBL7081171 | 0.83 | SIGMAR1 (0.56) | HTR1ADRD4DRD3SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL6959307 | 0.82 | SIGMAR1 (0.56) | HTR1ADRD4DRD3SIGMAR1DRD2 | |
| SCHEMBL7080999 | 0.76 | DRD2 (0.55) | HTR1ADRD4DRD3HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL6950618 | 0.76 | DRD2 (0.54) | HTR1ADRD4DRD3HTR2AHTR2C | |
| SCHEMBL6952207 | 0.73 | HTR1A (0.49) | HTR1ADRD4DRD3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851862-B1 | 1(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF 5-HT1A-RECEPTOR MEDIATED DISORDERS | PHARMACIA ITALIA SPA (IT) | 2003-09-10 | — | — | EP | claimed |