Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.49 |
| ▸ | HTR7 | P34969 | 9/20 | 0.49 |
| ▸ | DRD2 | P14416 | 8/20 | 0.49 |
| ▸ | DRD3 | P35462 | 7/20 | 0.49 |
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6959796 | 0.99 | HTR1A (0.48) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL6952045 | 0.97 | DRD3 (0.53) | HTR1AHTR7DRD2DRD3HTR2A | |
| Hydrochloric Acid SCHEMBL6960476 | 0.96 | DRD3 (0.52) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL7081609 | 0.92 | DRD2 (0.46) | HTR1AHTR7DRD2DRD3HTR2A | |
| Hydrochloric Acid SCHEMBL6957118 | 0.91 | DRD2 (0.45) | HTR1AHTR7DRD2DRD3HTR2A | |
| SCHEMBL7082241 | 0.86 | SIGMAR1 (0.52) | HTR1ADRD2DRD3DRD1DRD4 | |
| SCHEMBL6953511 | 0.85 | ADORA1 (0.47) | HTR7DRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL6956636 | 0.85 | DRD2 (0.52) | HTR1ADRD2DRD3DRD1DRD4 | |
| Hydrochloric Acid SCHEMBL6959246 | 0.84 | ADORA1 (0.46) | HTR7DRD2DRD3DRD4 | |
| SCHEMBL7084707 | 0.83 | SIGMAR1 (0.57) | HTR1ADRD2DRD3DRD4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851862-B1 | 1(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF 5-HT1A-RECEPTOR MEDIATED DISORDERS | PHARMACIA ITALIA SPA (IT) | 2003-09-10 | — | — | EP | claimed |
| EP-0851862-B1 | 1(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF 5-HT1A-RECEPTOR MEDIATED DISORDERS | PHARMACIA ITALIA SPA (IT) | 2003-09-10 | — | — | EP | disclosed |