Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042720 | 0.85 | SLC6A4 (0.42) | SLC6A4PTGER1PAX8SLC6A3KDM2B | |
| SCHEMBL7079008 | 0.82 | REN (0.42) | SLC6A4SLC6A3 | |
| SCHEMBL7081269 | 0.80 | REN (0.47) | SLC6A4SLC6A3 | |
| SCHEMBL7082510 | 0.78 | REN (0.49) | — | |
| SCHEMBL7084411 | 0.78 | REN (0.39) | SLC6A4SLC6A3 | |
| SCHEMBL7078125 | 0.76 | REN (0.38) | SLC6A4SLC6A3 | |
| SCHEMBL7081090 | 0.76 | REN (0.38) | SLC6A4SLC6A3 | |
| SCHEMBL7083931 | 0.75 | KDM2B (0.36) | PTGER1KDM2B | |
| SCHEMBL7080911 | 0.73 | REN (0.37) | KDM2B | |
| SCHEMBL6041889 | 0.72 | SLC6A3 (0.38) | SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |