Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 10/20 | 0.49 |
| ▸ | THRB | P10828 | 10/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088864 | 0.85 | THRA (0.47) | THRATHRBKDRARHTR1A | |
| SCHEMBL7082352 | 0.84 | THRA (0.69) | THRATHRBHTR2BHTR1AHTR2A | |
| SCHEMBL7088178 | 0.84 | THRA (0.52) | THRATHRBHTR2BTRPM8HTR1A | |
| SCHEMBL7082348 | 0.84 | THRA (0.55) | THRATHRBKDRHTR2BTRPM8 | |
| SCHEMBL7085460 | 0.82 | THRA (0.48) | THRATHRBCYP1A2HTR2A | |
| SCHEMBL7085754 | 0.82 | THRA (0.48) | THRATHRBTRPM8HTR1AHTR1D | |
| SCHEMBL7088630 | 0.81 | THRA (0.47) | THRATHRBKDRHTR2BTRPM8 | |
| SCHEMBL7088760 | 0.81 | THRA (0.52) | THRATHRBHTR2BTRPM8HTR1A | |
| SCHEMBL7089038 | 0.80 | THRA (0.58) | THRATHRBARHTR2BHTR2A | |
| SCHEMBL7085031 | 0.80 | HTR1A (0.50) | THRATHRBTRPM8HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |