SCHEMBL7082385

SCHEMBL7082385

COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)NC(=O)N1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTDSP1 Q9GZU7 1/20 0.58
ADRA1A P35348 5/20 0.51
KMT2A Q03164 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
TP53 P04637 1/20 0.49
MEN1 O00255 1/20 0.49
GAA P10253 4/20 0.48
KDM4E B2RXH2 2/20 0.46
ALDH1A1 P00352 2/20 0.46
ALOX15 P16050 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
MITF O75030 1/20 0.46
MAPT P10636 1/20 0.46
KLF5 Q13887 1/20 0.46
ADRA1D P25100 3/20 0.46
ADRA1B P35368 3/20 0.46
GUSB P08236 1/20 0.46
POLB P06746 1/20 0.45
TSHR P16473 1/20 0.45
MAPK1 P28482 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6645152 1.00 CTDSP1 (0.58) CTDSP1ADRA1AKMT2AL3MBTL1TP53
SCHEMBL7082388 1.00 CTDSP1 (0.58) CTDSP1ADRA1AKMT2AL3MBTL1TP53
SCHEMBL7638902 0.89 ADRA1A (0.50) CTDSP1ADRA1AKMT2AMEN1GAA
SCHEMBL6686591 0.89 ADRA1A (0.50) CTDSP1ADRA1AKMT2AMEN1GAA
SCHEMBL8690693 0.89 CTDSP1 (0.53) CTDSP1KMT2AL3MBTL1TP53MEN1
SCHEMBL4503574 0.87 ALDH1A1 (0.58) CTDSP1KMT2AL3MBTL1TP53MEN1
SCHEMBL19752687 0.83 GUSB (0.64) KMT2AL3MBTL1TP53GAAKDM4E
SCHEMBL19752623 0.83 GUSB (0.64) KMT2AL3MBTL1TP53GAAKDM4E
SCHEMBL7082392 0.76 ADRA1A (0.61) ADRA1AADRA1DADRA1B
SCHEMBL6193377 0.76 ADRA1D (0.42) ADRA1AKMT2AMEN1GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0998285-A4 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2003-01-08 EP disclosed
US-6410554-B1 ADRENERGIC ANTAGONIST MERCK & CO., INC. 2002-06-25 US disclosed
US-6320049-B1 PREPARING 1-AMINOCARBONYL-5-ACYLDEHYDROPYRIMIDONES BY DEPROTONATING 5-ACYLDIHYDROPYRIMIDINONES COMPOUND AND THEN COUPLING THE DEPROTONATED DERIVATIVE WITH A PRIMARY AMINE MERCK & CO., INC. 2001-11-20 US disclosed
US-6207444-B1 CONTACTING RACEMIC COMPOUND WITH PROTEINASE K, SUBTILISIN, OR A PROTEASE ENZYME FROM METARHIZIUM TO FORM ENANTIOMORPH; CHEMICAL INTERMEDIATE OF DRUG WHICH TREATS BENIGN PROSTATIC HYPERPLASIA MERCK & CO., INC. 2001-03-27 US disclosed
EP-1003734-A2 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST Merck & Co., Inc. (US) 2000-05-31 EP disclosed
EP-0998285-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 2000-05-10 EP disclosed
WO-1999007695-A2 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST MERCK & CO., INC. (US) 1999-02-18 WO disclosed
WO-1998057641-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1998-12-23 WO disclosed