Sugi Predict

Sugi Predict / Compounds / SCHEMBL6645152

SCHEMBL6645152

SCHEMBL6645152

COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)NC(=O)N1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CTDSP1 Q9GZU7 1/20 0.58
▸ ADRA1A P35348 5/20 0.51
▸ KMT2A Q03164 2/20 0.49
▸ L3MBTL1 Q9Y468 1/20 0.49
▸ TP53 P04637 1/20 0.49
▸ MEN1 O00255 1/20 0.49
▸ GAA P10253 4/20 0.48
▸ KDM4E B2RXH2 2/20 0.46
▸ ALDH1A1 P00352 2/20 0.46
▸ ALOX15 P16050 2/20 0.46
▸ TDP1 Q9NUW8 2/20 0.46
▸ MITF O75030 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ KLF5 Q13887 1/20 0.46
▸ ADRA1D P25100 3/20 0.46
▸ ADRA1B P35368 3/20 0.46
▸ GUSB P08236 1/20 0.46
▸ POLB P06746 1/20 0.45
▸ TSHR P16473 1/20 0.45
▸ MAPK1 P28482 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7082385 1.00 CTDSP1 (0.58) CTDSP1ADRA1AKMT2AL3MBTL1TP53
SCHEMBL7082388 1.00 CTDSP1 (0.58) CTDSP1ADRA1AKMT2AL3MBTL1TP53
SCHEMBL7638902 0.89 ADRA1A (0.50) CTDSP1ADRA1AKMT2AMEN1GAA
SCHEMBL6686591 0.89 ADRA1A (0.50) CTDSP1ADRA1AKMT2AMEN1GAA
SCHEMBL8690693 0.89 CTDSP1 (0.53) CTDSP1KMT2AL3MBTL1TP53MEN1
SCHEMBL4503574 0.87 ALDH1A1 (0.58) CTDSP1KMT2AL3MBTL1TP53MEN1
SCHEMBL19752687 0.83 GUSB (0.64) KMT2AL3MBTL1TP53GAAKDM4E
SCHEMBL19752623 0.83 GUSB (0.64) KMT2AL3MBTL1TP53GAAKDM4E
SCHEMBL7082392 0.76 ADRA1A (0.61) ADRA1AADRA1DADRA1B
SCHEMBL6193377 0.76 ADRA1D (0.42) ADRA1AKMT2AMEN1GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040242609-A1 Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof SYNAPTIC PHARMACEUTICAL CORPORATION 2004-12-02 — — US disclosed
EP-1299362-A4 SELECTIVE MELANIN CONCENTRATING HORMONE-1 (MCH1) RECEPTOR ANTAGONISTS AND USES THEREOF SYNAPTIC PHARMA CORP (US) 2004-11-03 — — EP disclosed
WO-2004064774-A2 DNA ENCODING A HUMAN MELANIN CONCENTRATING HORMONE RECEPTOR (MCH1) AND USES THEREOF SYNAPTIC PHARMACEUTICAL CORPORATION (US) 2004-08-05 — — WO disclosed
US-20040138242-A1 Dihydropyrimidines and uses thereof MERCK AND CO., INC. 2004-07-15 — — US disclosed
US-6720324-B2 THERAPY FOR EATING DISORDERS, SEXUAL DISORDERS, PSYCHOLOGICAL DISORDERS SYNAPTIC PHARMACEUTICAL CORPORATION 2004-04-13 — — US disclosed
US-20040038855-A1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof H. LUNDBECK A/S (DK) 2004-02-26 — — US disclosed
US-6680323-B2 SELECTIVE ANTAGONISTS FOR HUMAN ALPHA 1A RECEPTORS; BENIGN PROSTATIC HYPERPLASIA; (+)-1-3-((4-(3,4-DIFLUOROPHENYL)-2,5-DIOXO-1,2,5,7-TETRAHYDRO-4H-FURO(3,4 -D)PYRIMIDINE-3-CARBONYL)AMINO)-PROPYL-4-(2-PYRIDYL)-PIPERIDINE SYNAPTIC PHARMACEUTICAL CORPORATION 2004-01-20 — — US disclosed
US-20030082623-A1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof H. LUNDBECK A/S (DK) 2003-05-01 — — US disclosed
US-20030077701-A1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof H. LUNDBECK A/S (DK) 2003-04-24 — — US disclosed
US-20030069261-A1 Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof H. LUNDBECK A/S (DK) 2003-04-10 — — US disclosed
US-6037354-A ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION MERCK & CO., INC. (US) 2000-03-14 — — US disclosed
WO-2000006565-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 2000-02-10 — — WO disclosed
WO-1999048530-A1 COMBINATION THERAPY FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA MERCK & CO., INC. (US) 1999-09-30 — — WO disclosed
WO-1999007695-A2 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST MERCK & CO., INC. (US) 1999-02-18 — — WO disclosed
WO-1998057638-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1998-12-23 — — WO disclosed
WO-1998057641-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1998-12-23 — — WO disclosed
WO-1998057639-A1 ALPHA 1aADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1998-12-23 — — WO disclosed
WO-1998057642-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1998-12-23 — — WO disclosed
WO-1998057640-A1 ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1998-12-23 — — WO disclosed
US-5786472-A CATALYTIC CONDENSATION OF UREA WITH DIKETONES USIN BORON REAGENT AND ACID CATALYST MERCK & CO., INC. (US) 1998-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030082623-A1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof MCHR1, MCHR2, MC1R CTDSP1 1296/4885ADRA1A 224/4885KMT2A 588/4885
US-20040138242-A1 Dihydropyrimidines and uses thereof QDPR, DPYD, ADRA1D CTDSP1 3436/4885ADRA1A 4/4885KMT2A 2204/4885
US-20040038855-A1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof MCHR1, MCHR2, MC1R CTDSP1 1405/4885ADRA1A 88/4885KMT2A 789/4885
US-20040242609-A1 Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof MCHR1, MCHR2, MC4R CTDSP1 4793/4885ADRA1A 161/4885KMT2A 1155/4885
US-20030077701-A1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof MCHR1, MCHR2, MC1R CTDSP1 1296/4885ADRA1A 224/4885KMT2A 588/4885
US-20030069261-A1 Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof MCHR1, MCHR2, MC4R CTDSP1 4793/4885ADRA1A 161/4885KMT2A 1155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.