Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | DRD3 | P35462 | 5/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487287 | 0.98 | DRD2 (0.44) | DRD2DRD3PRKCIDYRK1ADYRK1B | |
| SCHEMBL15290407 | 0.95 | DRD2 (0.45) | DRD2DRD3PRKCIDYRK1ADYRK1B | |
| SCHEMBL984492 | 0.87 | PRKCI (0.48) | DRD2DRD3PRKCIDYRK1ADYRK1B | |
| SCHEMBL31452888 | 0.86 | CLK1 (0.40) | DRD2DRD3PRKCIDYRK1ADYRK1B | |
| SCHEMBL31540883 | 0.85 | PRKCI (0.47) | DRD2DRD3PRKCIDYRK1ADYRK1B | |
| SCHEMBL31540886 | 0.85 | PRKCI (0.47) | DRD2DRD3PRKCIDYRK1ADYRK1B | |
| SCHEMBL10487375 | 0.78 | DRD2 (0.48) | DRD2DRD3PRKCIMTNR1AMTNR1B | |
| SCHEMBL12333251 | 0.77 | ADCY6 (0.42) | DRD2DRD3PRKCIDYRK1ADYRK1B | |
| SCHEMBL7204153 | 0.76 | CLK1 (0.40) | PRKCIDYRK1ADYRK1BCLK1MTNR1A | |
| SCHEMBL22744291 | 0.76 | ASIC3 (0.34) | DRD2DRD3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765877-B1 | 5,6,7,8-Tetrahyronaphto(2,3-b)furan- and indano(5,6-b)furan-amino-compounds, processes for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-12-17 | — | — | EP | disclosed |
| EP-0765877-A1 | 5,6,7,8-Tetrahyronaphto(2,3-b)furan- and indano(5,6-b)furan-amino-compounds, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1997-04-02 | — | — | EP | disclosed |
| US-4885373-A | AMINE DERVIVATIVES USED AS ANTIDEPRESSANT AND DOPAMINERGIC STIMULANTS | ADIR ET CIE (FR) | 1989-12-05 | — | — | US | disclosed |
| US-4874878-A | CHEMICAL INTERMEDIATES FOR ANTIDEPRESSANTS | ADIR ET CIE (FR) | 1989-10-17 | — | — | US | disclosed |
| US-4863951-A | ANTIDEPRESSANTS, ANTIAGRESSIVES, DOPAMINERGIC PROPERTIES | ADIR ET CIE (FR) | 1989-09-05 | — | — | US | disclosed |
| US-4851429-A | ANTIDEPRESSANT, TRANQUILIZERS | ADIR ET CIE (FR) | 1989-07-25 | — | — | US | disclosed |
| US-4851429-A | ANTIDEPRESSANT, TRANQUILIZERS | ADIR ET CIE (FR) | 1989-07-25 | — | — | US | disclosed |