Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 4/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 6/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083553 | 0.87 | ABCB11 (0.51) | ABCB11PTGER4CCR2S1PR3TRPM8 | |
| SCHEMBL7089675 | 0.79 | ABCB11 (0.48) | ABCB11CCR2S1PR3PPARGMAPT | |
| SCHEMBL7088120 | 0.77 | ABCB11 (0.74) | ABCB11CCR2PPARG | |
| SCHEMBL7086963 | 0.76 | ABCB11 (0.55) | ABCB11CCR2PPARGMAPTPKM | |
| SCHEMBL7084277 | 0.74 | ABCB11 (0.63) | ABCB11CCR2 | |
| SCHEMBL7601514 | 0.73 | GAA (0.41) | ABCB11PPARGMAPTPKMKDM4E | |
| SCHEMBL7083775 | 0.71 | ABCB11 (0.78) | ABCB11CCR2PPARGMAPTPKM | |
| SCHEMBL6599182 | 0.67 | ABCB11 (0.73) | ABCB11CCR2 | |
| SCHEMBL6781272 | 0.65 | ABCB11 (0.71) | ABCB11CCR2 | |
| SCHEMBL6598122 | 0.65 | ABCB11 (0.74) | ABCB11CCR2MAPTPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030144339-A1 | Indole derivatives as mcp-1 receptor antagonists | ASTRAZENECA AB (SE) | 2003-07-31 | — | — | US | claimed |
| CN-1395565-A | Indole derivatives as MCP-1 receptor antagonists | ASTRAZENECA AB (SE) | 2003-02-05 | — | — | CN | claimed |
| EP-1252142-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2002-10-30 | — | — | EP | claimed |
| WO-2001051466-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-07-19 | — | — | WO | claimed |
| US-20030144339-A1 | Indole derivatives as mcp-1 receptor antagonists | ASTRAZENECA AB (SE) | 2003-07-31 | — | — | US | disclosed |
| CN-1395565-A | Indole derivatives as MCP-1 receptor antagonists | ASTRAZENECA AB (SE) | 2003-02-05 | — | — | CN | disclosed |
| EP-1252142-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001051466-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144339-A1 | Indole derivatives as mcp-1 receptor antagonists | CCR2, CCR1, CCR5 | ABCB11 391/4885PTGER4 503/4885CCR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.